Can Meds Stop Excessive Armpit Sweating?


There are a number of oral medications available and known to be prescribed by some doctors to help stop excessive armpit sweating. These known medications are from the several families of drugs.

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Anticholinergics (such as Robinul)

There are no known drugs for the specific treatment of primary Hyperhidrosis. However, excess sweating can be treated with some success with systemic anticholinergics. These drugs have many unpleasant side effects including dilated pupils, constipation, urinary retention and heart palpitation. The most common side effect of these medications is severe dry mouth, which is unacceptable by many patients.

Beta-Blockers (such as Inderal)

These medications have systemic anti-sympathetic effects that are helpful in decreasing the body’s sympathetic response. They have been useful in some cases of stress related excessive sweating. They also decrease palpitation and tremors, and are mostly useful when taken one or two hours before a stressful situation.

Antidepressants and Anti-Anxiety Medications

These medications have been used to treat Hyperhidrosis. However, it should be noted that depression is not a cause of excessive sweating.  However, excessive and uncontrollable sweating can be a direct cause of depression.

Propantheline Bromide (Probanthine)

This medication causes a systemic decrease in sympathetic response. Other medical uses include treating high blood pressure and some arrhythmia. This medication should only be administered after a thorough examination of the patient.


Medications are not a permanent solution as their effectiveness will stop when you stop taking the medication. Results are mixed…some claim a complete cure for eSweaty Backxcessive armpit sweating with little or no side effects to those that saw no change in their Hyperhidrosis with multiple side effects, the most common being severe dry mouth.

There are potential side effects to be considered prior to beginning any drug treatment.  And oral medications are not an inexpensive excessive sweating treatment alternative.  The latest price quote from MedRx.com for Robinul runs about $300 for a 60 day supply.

Robinul, Robinul Forte, Avert (Canada), Secure  - Genric = Glycopyrrolate

These medications belong to a anticholinergic  family of drugs.  Glycopyrrolate’s primary use is to reduce the secretions of certain organs in the body.  It helps to control conditions such as peptic ulcers that involve excessive stomach acid production but can also be prescribed to stop excessive armpit sweating.

Use caution when driving, operating machinery, or performing other hazardous activities. Glycopyrrolate may cause dizziness, drowsiness, or blurred vision. If you experience dizziness, drowsiness, or blurred vision, avoid these activities. Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while you are taking glycopyrrolate.

Avoid becoming overheated in hot weather. Glycopyrrolate increases the risk of heat stroke due to its cause of decreased sweating.

They have an anticholinergic effect which in essence blocks the neuro-transmission responsible for the production of sweat. It may come as a surprise that none of these medications are specifically made for treating Hyperhidrosis.  But one side effect is that causing dryness, obviously a condition sought after my people who suffer from excessive sweating.

In addition to dryness, other side effects can include:

  • an allergic reaction such as difficulty breathing, closing of the throat, swelling of your lips, tongue, or face; hives
  • an irregular or fast heart rate;
  • rash or flushing; or
  • eye pain.
  • blurry vision,
  • dry mouth, etc.
  • Other, less serious side effects may be more likely to occur:
  • headache, dizziness, or lightheadedness;
  • weakness or nervousness;
  • blurred vision, large pupils, or sensitivity of the eyes to bright light;
  • nausea, bloating, heartburn, or constipation;
  • changes in taste;
  • difficulty urinating;
  • decreased sweating; or
  • nasal congestion or stuffiness.

Ditropan, Ditroban XL, Urotrol – Generic = Oxybutynin

Ditropan primary use is to reduce muscle spasms of the bladder and urinary tract but is also used to control excessive sweating.

Pro-Banthine – Generic = Propantheline

Propantheline reduces the secretions of certain organs in the body and helps control conditions such as peptic ulcers that involve excessive stomach acid production.  Although not approved by the FDA for these purposes, propantheline has been used to treat other conditions involving spasms or excessive secretion such as profuse, uncontrolled sweating.

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